![]() doi: 10.1016/j.cgh.2014.01.038 (quiz e103)Īmaral AF, Porta M, Silverman DT, Milne RL, Kogevinas M, Rothman N, Cantor KP, Jackson BP, Pumarega JA, López T, Carrato A, Guarner L, Real FX, Malats N (2012) Pancreatic cancer risk and levels of trace elements. doi: 10.1093/carcin/bgs112Īlsamarrai A, Das SL, Windsor JA, Petrov MS (2014) Factors that affect risk for pancreatic disease in the general population: a systematic review and meta-analysis of prospective cohort studies. doi: 10.1136/oemed-2011-100111Īhn J, Segers S, Hayes RB (2012) Periodontal disease, Porphyromonas gingivalis serum antibody levels and orodigestive cancer mortality. doi: 10.1038/sj.bjc.6604880Īdams SV, Passarelli MN, Newcomb PA (2012) Cadmium exposure and cancer mortality in the Third National Health and Nutrition Examination Survey cohort. ![]() doi: 10.1158/1055-9965.EPI-15-1115Ībnet CC, Freedman ND, Kamangar F, Leitzmann MF, Hollenbeck AR, Schatzkin A (2009) Non-steroidal anti-inflammatory drugs and risk of gastric and oesophageal adenocarcinomas: results from a cohort study and a meta-analysis. Cancer Epidemiol Biomarkers Prev 25:555–557. Moreover, the identification of these factors could facilitate the development of strategies for an early diagnosis or measures of risk reduction for high-risk people.Ībe SK, Inoue M, Sawada N, Iwasaki M, Shimazu T, Yamaji T, Sasazuki S, JPHC Study Group, Saito E, Tanaka Y, Mizokami M, Tsugane S, JPHC Study Group (2016) hepatitis B and C virus infection and risk of pancreatic cancer: a population-based cohort study (JPHC Study Cohort II). The identification of the factors involved in PC initiation and progression could be of help in establishing novel therapeutic approaches by targeting the molecular signaling pathways responsive to these stimuli. Protective agents include dietary flavonoids, marine omega-3, vitamin D, fruit, vegetables, and the habit of regular physical activity. However, some of these agents act both as initiators and promoters in pancreatic acinar cells. Moreover, pancreatitis, high doses of alcohol drinking, the body microbial infections, obesity, diabetes, gallstones and/or cholecystectomy, and the accumulation of asbestos fibers seem to play a crucial role in the progression of the disease. Among the most dangerous agents involved in the initiation phase, there are the inhalation of cigarette smoke, and the exposure to mutagenic nitrosamines, organ-chlorinated compounds, heavy metals, and ionizing radiations. ![]() Here, we analyzed the most recently published case–control association studies, meta-analyses, and cohort studies with the aim to summarize the main environmental factors that could have a role in PC. Only 10 % of all PC cases are thought to be due to genetic factors. Pancreatic cancer (PC) is one of the most aggressive diseases. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |